Our research interests involve studying the function, dynamics, and physico-chemical properties of nanoscale assemblies to understand their activities in the cell. The main object of our studies is the ribosome - the macromolecular complex responsible for protein synthesis.
The focus of our research is to extend, apply and verify experimentally simulation techniques to study the association of ligands with the ribosomal RNA. The goal is to explore ribosomal internal motions and electrostatic properties, as well as the thermodynamics and kinetics of binding of antibiotics inhibiting the bacterial ribosome.
Research areas include:
- physicochemical properties of macromolecular complexes
- design of ligands targeting the bacterial ribosome
- thermodynamics of interactions between modified oligonucleotides
- coarse-grained models for proteins and nucleic acids
- molecular dynamics simulations of RNA systems
- academic software development for molecular modeling and simulations
We combine theoretical approaches (computational simulations and molecular modeling) with experimental biophysical measurements (absorbance, fluorescence, circular dichroism spectroscopy, isothermal titration calorimetry).