Molecular machines are nanoscale macromolecular complexes performing specific functions for an organism. Cells build thousands of such custom-designed complexes including the ribosome, transcriptional machinery, motors and transporters, all of which work in a precisely organized manner. Joanna Trylska and her group explore the function, dynamics, and physical properties of macromolecules to understand their activities in the cell. The ultimate goal is to search for antibiotic analogs, antisense modified oligonucleotides and their conjugates that would inhibit the function of bacterial RNA.
