First hybrid PNA–AAV vectors: combining chemical simplicity with biological intelligence in an innovative platform for the delivery of modified oligonucleotides
This project aims to develop a novel hybrid platform for delivering peptide nucleic acids (PNA) to eukaryotic cells using adeno-associated virus (AAV) vectors.
By combining the high chemical stability of PNA with the biological precision and tissue tropism of AAV, the project seeks to enable efficient and selective gene silencing in liver cells. This proof-of-concept study represents a significant step toward developing new tools for gene expression regulation, with strong translational potential for future therapeutic applications in cancer and genetic diseases.
Principal Investigator: Prof. dr hab. Joanna Trylska, CeNT UW, and Prof. Leszek Lisowski, Military Institute of Medicine – National Research Institute (WIM-PIB)
Project period: 2026
Funding: “Excellence Initiative – Research University (2020-2026)”, a programme of the Ministry of Science and Higher Education
