Name: Monika Wojciechowska

Current Position: research assistant, Centre of New Technologies, University of Warsaw

Contact: email: m.wojciechowska@cent.uw.edu.pl

phone: +48 22 55 43 635

Office Address: Centre of New Technologies, University of Warsaw, Banacha 2C, 02-097 Warsaw, Poland

 

Education:

  • October 2009 – June 2014    Ph.D. in organic chemistry at the Faculty of Chemistry, University of Gdansk. Thesis Title: “Design and synthesis of peptide nucleic acid conjugated with a cell penetrating peptides”.
  • October 2004 – June 2009    MSc degree in chemistry, University of Gdansk, Faculty of Chemistry, Diploma seminar in the field: Chemistry of biologically active compounds. Thesis Title: “Synthesis of nucleotide derivatives of amino acids”.

Conferences and Workshops:

  • M. Wojciechowska, J. Macyszyn, J. Miszkiewicz, J. Trylska “Stapled α-helical peptides: Application in antibacterial therapies” ACS Spring 2021, Macromolecular Chemistry: The Second Century, 2021
  • M. Wojciechowska, J. Trylska “The effect of lipid environments on the secondary structure of membrane-active peptides” Biophysical Society 65th Annual Meeting, 2021
  • M. Wojciechowska, J. Miszkiewicz, J. Trylska “Modifications of anoplin that stabilize its α-helical structure and enhance antibacterial activity” 28th Young Researchers Days Meeting, Web-meeting, Paris, France, 2021
  • M. Wojciechowska, J. Miszkiewicz, J. Trylska, “Structural changes of membrane-active peptides upon interactions with micelles, liposomes and bacteria”, PepTalk 2021, The Protein Science and Production Week, 19-21.01.2021, Virtual conference and expo
  • Wojciechowska M, Równicki M, Wierzba A, Gryko D, J Trylska „Delivery of peptide nucleic acids into bacterial cells by vitamin B12 and future applications of their conjugations in antibacterial therapy” EUROBIOTECH 2019. Krakow, Poland, 2019
  • Wojciechowska M, Równicki M, Wierzba A, Gryko D, J Trylska “Applications of peptide nucleic acid oligomers as an antibacterial strategy” 62 Zjazd PTChem, Warsaw, Poland, 2019
  • Wojciechowska M., Dudek M., Trylska J. “Structure of the pseudo-knot in the helix 18 of Escherichia coli 16S rRNA” Workshop: RNA structure, dynamics and function, SISSA in Trieste, Italy, 2016.
  • Wojciechowska M., Chromiński M., Wierzba A., Równicki M., Dąbrowska Z., Gryko D., Trylska J., “Vitamin B12 as a delivery vehicle for antibacterial peptide nucleic acids” 23 Polish Peptide Symposium, Spala, Poland, 2015.
  • Wojciechowska M., Trylska J., “Interactions of peptide nucleic acids with ribosomal RNA helix 18”, EMBO Young Scientists Forum, Warsaw, Poland, 2015.
  • Wojciechowska M., Trylska J., “Interactions of peptide nucleic acids with ribosomal RNA helix 18”, Multi-Pole Approach to Structural Science, Warsaw, Poland, 2015.
  • Wojciechowska M., Trylska J., “Interactions of peptide nucleic acids with helix 18 of E. coli 16S ribosomal RNA”, Biomolecules and Nanostructures 5, Jaroszowice, Poland, 2015.
  • Wojciechowska M., Ruczyński J., Mucha P., Alenowicz M., Pieszko M., Miszka A., Dobkowski M., Hans A.R. Bluijssen, Rekowski P., „Synthesis and hybridization studies of PNA-CPP conjugates – new inhibitors of STAT1 mRNA”, 22nd Polish Peptide Symposium, Kudowa Zdroj, Poland, 2013.
  • Wojciechowska M., Rekowski P., Alenowicz M., Ruczyński J., Szeląg M., Sikorski K., Wesoły J., Bluijssen H., „Synthesis of New inhibitors of STAT1 mRNA as attractive compounds in treatment of atherosclerosis”, European Peptide Symposium, Athens, Greece, 2012.
  • Wojciechowska M., Malcher J., Alenowicz M., Ruczyński J., Sikorski K., Wesoły J., Bluijssen H., Rekowski P., „Application of the click chemistry in the synthesis of PNA conjugates with cell penetrating peptides, as a chance of successful treatment of Atherosclerosis” Early Stage Researcher Meeting, Londyn, England, 2012.
  • Wojciechowska M., Alenowicz M., Ruczyński J., Mucha P., Rekowski P., Bluijssen H.,  „Synteza koniugatów   PNA-CPP jako szansa skutecznego leczenia miażdżycy”, 55 Zjazd PTChem i SITPChem, Bialystok, Poland, 2012.

Publications:

  • Monika Wojciechowska, Julia Macyszyn, Joanna Miszkiewicz, Renata Grzela, Joanna Trylska, Stapled anoplin as an antibacterial agent, Frontiers in Microbiology, 12:772038, 2021, doi: 10.3389/fmicb.2021.772038
  • Aleksandra J. Wierzba, Monika Wojciechowska, Joanna Trylska, Dorota Gryko, Vitamin B12: Peptide Nucleic Acid Conjugates, Peptide Conjugation: Methods and Protocols, in Methods in Molecular Biology, Springer Nature, 2021, vol. 2355, chapter 7, https://doi.org/10.1007/978-1-0716-1617-8_7
  • Tomasz Pieńko, Jakub Czarnecki, Marcin Równicki, Monika Wojciechowska, Aleksandra J. Wierzba, Dorota Gryko, Dariusz Bartosik, Joanna Trylska, Vitamin B12-peptide nucleic acids use the BtuB receptor to pass through the E. coli outer membrane, Biophys. J., 120:725–737, 2021, doi: 10.1016/j.bpj.2021.01.004
  • Monika Wojciechowska, Joanna Miszkiewicz, Joanna Trylska, Conformational changes of anoplin, W-MreB1-9 and (KFF)3K peptides in proximity to membrane environments, Int. J. Mol. Sci., 21:9672, 2020, doi:10.3390/ijms21249672
  • Agnieszka Popielec, Natalia Ostrowska, Monika Wojciechowska, Michael Feig, Joanna Trylska, The effect of the crowded environment on the activity and inhibition of the NS3/4A protease, Biochimie, 176:169-180, 2020, doi: 10.1016/j.biochi.2020.07.009.
  • M. Wojciechowska, M. Równicki, A. Mieczkowski, J. Miszkiewicz, J. Trylska, Antibacterial peptide nucleic acids – facts and perspectives, Molecules, 25(3), 559, 2020, cover figure
  • M. Równicki, Z. Dąbrowska, M. Wojciechowska, A. J. Wierzba, K. Maximova, D. Gryko, J. Trylska, Inhibition of Escherichia coli growth by vitamin B12-peptide nucleic acid conjugates, ACS Omega, 4(1):819-824, 2019
  • A. J. Wierzba, K. Maximova, A. Wincenciuk, M. Równicki, M. Wojciechowska, E. Nexo, J. Trylska, D. Gryko, Does a conjugation site affect transport of vitamin B12-PNA conjugates into bacterial cells?, Chemistry – A European Journal, 24(70):18772-18778, 2018
  • J. I. Castillo, M. Równicki, M. Wojciechowska, J. Trylska, Antimicrobial synergy between mRNA targeted peptide nucleic acid and antibiotics in E. coli, Bioorg. & Med. Chem. Lett.,  28: 3094–3098, 2018
  • M. Równicki, M. Wojciechowska, A. J. Wierzba, J. Czarnecki, D. Bartosik, D. Gryko, J. Trylska, Vitamin B12 as a carrier of peptide nucleic acid (PNA) into bacterial cells, Sci. Rep., 7:7644, 2017
  • T. Pieńko, A. J. Wierzba, M. Wojciechowska, D. Gryko, J. Trylska, Conformational dynamics of cyanocobalamin and its conjugates with peptide nucleic acids J. Phys. Chem. B., 121:2968-2979, 2017
  • Wierzba A., Wojciechowska M., Trylska J., Gryko D. „Vitamin B12 Suitably Tailored for Disulfide-Based Conjugation” Bioconjugate Chem., 2016, 27 (1),189–197.
  • Wojciechowska M., Ruczyński J., Rekowski P., Alenowicz M., Mucha P., Pieszko M., Miszka A., Dobkowski M., Bluijssen H. ”Synthesis and Hybridization Studies of a New CPP-PNA Conjugate as a Potential Therapeutic Agent in Atherosclerosis Treatment” Protein & Peptide Letters, 2014, 21, 672-678.
  • Machnik G., Łabuzek K, Skudrzyk E., Rekowski P, Ruczyński J., Wojciechowska M., Mucha P.,Okopień B. “Peptide nucleic acid (PNA) – mediated polymerase chain reaction clamping allows the selective amplification inhibition of ERVWE1, a syncytin-1 coding gene belonging to the HERV-W, an endogenous retroviral family” Molecular and Cellular Probes, 2014, 28, 1237-241.
  • Dobkowski M., Szychowska A., Pieszko M., Miszka A., Wojciechowska M., Alenowicz M., Ruczyński J., Rekowski P., Celewicz L., Barciszewski J., Mucha P. „‘Click’ chemistry synthesis and capillary electrophoresis study of 1,4-linked 1,2,3-triazole AZT-systemin conjugate” Journal of Peptide Science, 2014, 20, 696-703.
  • Wojciechowska M., Dobkowski M., Pieszko M., Ruczyński J., Mucha P., Rekowski P., Alenowicz M., „PNA – Peptide Nucleic Acids. Synthesis, properties and applications”, Copernican Letters, eds Szłyk E., Toruń (2012), vol.3/2012, 159-169, ISSN: 2082 968X.
  • Wojciechowska M., Alenowicz M., Ruczyński J., Szeląg M., Sikorski K., Wesoły J., Bluijssen H., Rekowski P., „Synthesis of New inhibitors of STAT1 mRNA as attractive compounds in treatment of atherosclerosis” Peptides 2012  (Proceedings of 32th European Peptide Symposium, Ateny, Grecja),  eds. Kokotos G., Constantinou-Kokotou V., Matsoukas J., 388-389 (2012) ISBN 978-960-466-121-3 Materiał pokonferencyjny.