IDUB New Ideas 3B (2023-2024)

In search of antibacterial peptides in phage endolysin structures

Recent literature suggests that peptides with antibacterial properties can be derived from phage endolysins, especially from those phages that infect Gram-negative bacteria. In this project, we proposed to use phage endolysins as sources of novel antibacterial peptides that interact with membranes. Peptide sequences with potential activity against Acinetobacter baumannii and other Gram-negative pathogens were identified and characterized. Preliminary studies, based on theoretical calculations and predictions, confirm that the designed peptides possess the properties responsible for their antibacterial character. In addition, modifications to the peptides were planned to enhance the activity and stability of the proposed compounds. The focus was on modifications affecting the stability of their active structures – helices.

Principal Investigator: dr Monika Wojciechowska, CeNT UW

Project period: Nov 1, 2023 – Nov 1, 2024

Funding: “Excellence Initiative – Research University (2020-2026)”, a programme of the Ministry of Science and Higher Education