Advanced photoluminescent platform for bacterial treatment (PHOBAT)
This project aims to develop a versatile platform of novel antibacterial agents. The platform will incorporate small luminescent organic compounds, such as triimidazo-triazine and naphthoquinolizinium derivatives, along with phosphorescent cyclometalated Pt(II) complexes, in combination with modified Peptide Nucleic Acids (PNAs). These compounds will be assessed for their potential as antimicrobial agents and PNA carriers, enabling the creation of dual-action systems. Such systems are designed to merge the antisense activity of PNAs with the therapeutic properties of the carrier, offering a synergistic approach to antibacterial treatment.
The project is a collaboration between the University of Warsaw, the University of Milan, and Charles University in Prague.
Funding: 4EU+, European University Alliance
